Category: Allgemein

Apr11

New research published: biochemical and biophysical background of the PTex method

Accompanying our recently published PTex protocol, we have published another manuscript at bioRxiv: “Fast and unbiased purification of RNA-protein complexes after UV cross-linking” provides important background information for the understanding of biphasic extractions and UV cross-linking of RNA-protein complexes as prerequisite to apply PTex.

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Apr11

Research update: RNA-binding prediction by machine learning

Together with our collaborators from the group of Annalisa Marsico (MPI for Molecular Genetics, Berlin), we have just published our machine learning approach to predict RNA-binding proteins: TriPepSVM. Read more about it in Nucleic Acids Research (Open Access): https://academic.oup.com/nar/advance-article/doi/10.1093/nar/gkz203/5421814

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Mar01

Research update: PTex, a new method to purify RNA-protein complexes published

We are very happy to announce that our latest work has been published in Nature Communications. We developed PTex, an unbiased and fast method to purify cross-linked RNA-protein complexes from a variety of biological sources.   We have a short summary of the method as well as other resources here.   The article itself is […]

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Nov09

New Research Published: TriPepSVM

Together with the RNA Bioinformatics group (MPI for Molecular Genetics, Berlin), we have just uploaded our latest work to bioRxiv: TriPepSVM¬†is a new machine learning approach to predict RNA-binding proteins in human and bacteria. We use a radically reductionist approach by only using short amino acid motifs to train a support vector machine (SVM) to […]

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