RNA-protein interactions have been studied intensively in recent years. Particularly novel methods such as mRNA interactome capture led to discovery of hundreds of novel RNA-binding proteins (RBPs). However, many of these recently identified RBPs lack classical RNA-binding domains.
In our review The expanding universe of ribonucleoproteins: of novel RNA-binding proteins and unconventional interactions, we discuss features of RNA-protein interactions and propose a more RNA-centric view: maybe RNA evolved to bind certain proteins rather than vice versa?
The article is open access and available here: Pflügers Archiv – European Journal of Physiology (2016)
or here: pubmed link